Intraocular sarcoidosis: association of clinical characteristics of uveitis with findings from 18F-labelled fluorodeoxyglucose positron emission tomography. Issue 1 (3rd April 2011)

• Record Type: Journal Article
• Authors: Rahmi, Ahmed; Deshayes, Emmanuel; Maucort-Boulch, Delphine; Varron, Loig; Grange, Jean Daniel; Kodjikian, Laurent; Seve, Pascal
• Is Part Of: British journal of ophthalmology. Volume 96:Issue 1(2012)
• Page Start: 99
• Page End: 103
• Publication Date: 2011-04-03
• Subjects: Uveitis, sarcoidosis -- PET scan -- fluorine-18 fluorodeoxyglucose positron emission tomography -- inflammation -- diagnostic tests/investigation; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.2010.194514
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Aims: To assess specific clinical criteria in patients with uveitis that are related to signs of sarcoidosis on 18 F-labelled fluorodeoxyglucose positron emission tomography ( 18 F-FDG-PET). Methods: Retrospective study of 54 consecutive patients with chronic uveitis for whom a PET scan was done because of suspected sarcoidosis, between July 2004 and December 2009. All the patients underwent a clinical examination, biological tests and a high-resolution CT of the chest. Results: 17 of the 54 patients (31.5%) presented hypermetabolic foci on 18 F-FDG-PET scan consistent with sarcoidosis. Among them eight patients (14.8%) underwent biopsy showing non-caseating granuloma. At the end of the study, 10 patients (18.5%) were considered as having a presumed sarcoidosis and seven patients (12.9%) as having indeterminate sarcoidosis. The increasing age at the diagnosis of uveitis (p=0.01), the presence of posterior synechiae (p=0.01) and a positive high-resolution CT of the chest (p=0.01) were significantly related to an abnormal PET scan. Conclusions: Increasing age at the diagnosis of uveitis, the presence of posterior synechiae and the positivity of high-resolution chest CT are associated with 18 F-FDG PET scan signs consistent with sarcoidosis.