IDDF2019-ABS-0105 Systematic review with meta-analysis: partial enteral nutrition for maintenance of remission in crohn's disease. (June 2019)

• Record Type: Journal Article
• Authors: Yang, Hongsheng; Qiu, Yun; Feng, Rui; Xu, Shu; Hao, Xiuxue; Zhang, Shenghong; Chen, Minhu
• Is Part Of: Gut. Volume 68(2019)Supplement 1
• Page Start: A78
• Page End: A79
• Publication Date: 2019-06
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2019-IDDFAbstracts.148
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Background: Extensive enteral nutrition, which exhibits therapeutic efficacy for induction of remission, is distinguished by having a good safety profile and improvements to growth parameters. However, it remains unclear whether partial enteral nutrition, i.e., enteral nutrition along with a daily diet, is as effective as exclusive enteral nutrition in maintaining remission of Crohn's disease (CD). We aim to evaluate the efficacy and safety of partial enteral nutrition for the maintenance of remission in CD by performing a systematic review and meta-analysis. Methods: Electronic databases were searched for prospective controlled studies evaluating partial enteral nutrition for maintenance of remission in CD. The primary outcome was clinical relapse as defined by the primary studies. Results: Three randomized controlled trials and five non-randomized controlled trials were included. The rate of clinical relapse, within a follow-up of 0.5–2 years, was significantly lower in CD patients receiving partial enteral nutrition (420 to 1800 kcal/d) than in those not receiving nutrition therapy (RR 0.58, 95% CI, 0.45–0.75, P <0.01; NNT = 5, P <0.01; n = 429). Among CD patients, those receiving partial enteral nutrition exhibited a higher frequency of maintaining clinical remission (defined as CDAI <150) at 1 year (63%, 89/141) than did those not receiving nutrition therapy (42%, 52/125; RR 1.47, 95% CI, 1.17–1.85, P <0.01). Adverse events caused by partial enteral nutrition were rare (7%, 9/131) and mild. Conclusions: Partial enteral nutrition appears to be more effective than the absence of enteral nutrition therapy for maintenance of remission in CD and has a good safety profile.