AB0557 NON-CORONARY CARDIAC MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS IN ADULTS. (June 2019)

• Record Type: Journal Article
• Authors: Ghriss, Nouha; sayhi, sameh; Boussetta, Najeh; Gueddich, Nour El Houda; Ajili, Faida; Abdelhafidh, Nadia Ben; Louzir, Bassem
• Is Part Of: Annals of the rheumatic diseases. Volume 78(2019)Supplement 2
• Page Start: 1740
• Page End: 1741
• Publication Date: 2019-06
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2019-eular.8191
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Systemic lupus erythematosus (SLE) is a common chronic multi-system autoimmune disorder of unknown etiology causing injury to many organ Systems. It predominantly affects young women. Cardiac manifestations develop in the majority of patients with SLE at some time during the course of their disease. Objectives: The aim of our study is to assess cardiac abnormalities in patients with systemic lupus erythematosus (SLE) by echocardiography and to compare the 2 groups of patients with and without cardiac manifestations. Methods: We have performed a transversal, descriptive study of SLE patients hospitalized in the Internal Medicine department at the Military Hospital of Tunis between January 2016 and June 2018. Diagnosis of SLE was made according to the criteria of ACR. All patients underwent a cardiac ultrasound externally or during their stay in our department. Results: The patients were 61 females and 19 males (sex-ratio=3) with a mean age of 38 years. Fourty two patients had cardiac involvement. They were 33 female and 9 male with a mean age of the disease of 31, 8 years (16-80 years) at the beginning of the disease and 41 years at the time of the study. 83% of patients were symptomatic. The symptoms were dominated by objectified chest pain (43%). In Doppler echocardiography, pericarditis was found in 23 patients (55%) with a single case of cardiac tamponade. Libman Saks endocarditis and lupus myocarditis were found in one case each. Pulmonory hypertension (HTP) was observed in 16 patients (38%) and valvular disease in 22 patients (52%). Cardiomegaly was observed in 9 patients (21%). Electrical abnormalities were dominated by microvoltage found in 8 patients. The general symptoms (83%), skin lesions (76%) and musculoskeletal involvement (64%) were the most frequent events associated with the cardiac manifestations in group 1. ANA were positive in 97% of cases and antiphospholipid antibodies in 24%. Prednisone: 1mg/kg/day and immunosuppressive therapy were indicated respectively in 71% and 38% of patients. Conclusion: Cardiac abnormalities are very common in lupus patients even when clinically asymptomatic. SLE is among systemic diseases most providers of heart disease. Echocardiography is an excellent non-invasive tool for cardiac evaluation. Their research must be systematic with echocardiography in order to reduce subsequent cardiac morbidity and mortality among the lupus patients. Disclosure of Interests: None declared