FRI0601 SERUM IMMUNOGLOBIN G4 LEVEL IN INHEPATITIS B WAS HIGHER THAN AUTOIMMUNE LIVER DISEASE IN A CHINESE POPULATION. (June 2019)

• Record Type: Journal Article
• Authors: Liao, Zetao; Zhang, Yanli
• Is Part Of: Annals of the rheumatic diseases. Volume 78(2019)Supplement 2
• Page Start: 996
• Page End: 996
• Publication Date: 2019-06
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2019-eular.8240
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: High serum level of Immunoglobulin G4 (IgG4) was detected in autoimmune hepatitis (AIH), but little was known in other types of hepatitis such as hepatitis B, primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Objectives: The aim of this study is to evaluate the level of serum IgG4 in hepatitis B and autoimmune liver disease. Methods: Hepatitis B and autoimmune liver disease patients were enrolled between January 1st and August 30th 2018. Diagnosis of Hepatitis B, AIH, PBC and PSC was basing on corresponding classification criteria, and established IgG4 related diseases were excluded. The levels of serum IgG4 were determined by nephelometric assay. The cut-off value of serum IgG4 was 2.01 g/L. Serum IgG4 among different liver diseases were compared. Results: 161 HBV hepatitis and 112 autoimmune liver diseases (52 AIH, 57 PBC, 3 PSC) were enrolled in this study. The HBV hepatitis patients were younger than patients with autoimmune liver disease (44.79±12.56 vs 52.52 ± 11.16 years old). In total, 61 patients (22.34%) had elevated serum IgG4 level. IgG4 level in HBV hepatitis was significantly higher than in AIH, PBC, respectively (1.64±1.80 vs 1.11±1.16, 1.64±1.80 vs 0.96±0.87 g/L, P<0.05). Conclusion: High serum IgG4 was very common in liver diseases without IgG4 related diseases especially in HBV hepatitis. Differential diagnosis should be made in patients with hepatitis accompanied with high serum IgG4. References: [1] No. Disclosure of Interests: None declared