AB0733 Association of haematological parameters with disease manifestations, activity, and severity in patients with systemic sclerosis. (12th June 2018)

• Record Type: Journal Article
• Authors: Yayla, M.E.; İlgen, U.; Okatan, I.E.; Uslu Yurteri, E.; Torğutalp, M.; Keleşoğlu Dinçer, A.B.; Aydemir Gülöksüz, E.G.; Sezer, S.; Turgay, T.M.; Kınıklı, G.; Ateş, A.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 1505
• Page End: 1505
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.2667
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), eosinophil-to-lymphocyte ratio (ELR), basophil-to-lymphocyte ratio (BLR), and mean platelet volume (MPV) may potentially reflect inflammatory status in systemic autoimmune diseases. Objectives: The aim of this study is to investigate the association of NLR, MLR, ELR, BLR and MPV with disease manifestations, activity and severity in patients with systemic sclerosis (SSc). Methods: 59 patients with SSc and 50 healthy controls were included in the study. All patients were diagnosed according to the 2013 ACR/EULAR systemic sclerosis classification criteria. Adult patients with SSc and healthy controls were compared in terms of NLR, MLR, ELR, BLR and MPV. Results: SSc and control groups had similar ages and genders. Lymphocyte number was lower in SSc group compared to controls (p<0.001). SSc group also have higher NLR and MLR (table 1). There were no significant differences in ELR and BLR ratios between SSc patients and controls. Patients with active disease (2.9 [IQR 2.13], p=0.042), pulmonary hypertension (PHT), digital ulcers, and tendon friction rubs (TFR) had higher NLRs (table 2). MLR was also higher in dcSSc patients (0.28 [IQR 0.73]) compared to lcSSc (0.2 [IQR 0.48] (p=0.045), and there were also significant associations with disease manifestations like digital ulcers, tendon friction rubs (table 2). MLR was positively correlated with mRSS (rho=0.35 p=0.009), Valentini (rho=0.453 p=0.001) and Medsger (rho=0.283 p=0.036) scores. According to capillaroscopy images, patients with late stage findings had higher MLRs compared to patients with normal findings (0.27 [IQR 0.3] vs 0.15 [IQR 0.04], p<0.001). Patients with digital ulcers (p=0.02) and arthritis (p=0.013) had higher ELRs and patients with tendon friction rubs has higher ELRs (p=0.014) and BLRs (0.036) compared to those without. There was no significant relation between MPV and disease manifestations (table 2). There were no relationships between dysmotility and haematological parameters. MPV, NLR and MLR are given as medians (interquartile ranges).+and – denote presence and absence, respectively. Conclusions: According to our study, as NLR and MLR are simple, practical, cost-effective markers, they can used for evaluation of disease manifestations, activity and severity in SSc. Disclosure of Interest: None declared