AB1083 IN A FAMILIAL MEDITERRANEAN FEVER PREVALENT REGION, ARE FAMILIAL MEDITERRANEAN FEVER AND BEHÇET'S DISEASE ASSOCIATED?. (June 2019)

• Record Type: Journal Article
• Authors: Alparslan, Ozgur; Egeli, Bugra Han; Demirel, Yeltekin; Ugurlu, Serdal
• Is Part Of: Annals of the rheumatic diseases. Volume 78(2019)Supplement 2
• Page Start: 2006
• Page End: 2006
• Publication Date: 2019-06
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2019-eular.3896
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: The co-existence of Familial Mediterranean Fever (FMF) and BehÇet's Disease (BD) has been questioned. There have been a variety of claims on a common pathogenesis. Objectives: We intended to report the prevalence of Familial Mediterranean Fever (FMF) and BehÇet's disease (BD) and comorbidity ratio of these two diseases in Sivas, Turkey, a city where FMF is known to be very high. Methods: Seventy-two primary schools in the center of Sivas participated in the study. A total of 14881 randomized sample children from 6th, 7th, and 8th grades, and also 985 of them with their parents (n: 978) were interviewed. During these interviews, the family tree up to second degree relatives was drawn. The presence of a diagnosis of FMF or BD was questioned. The ones who have a diagnosis were confirmed by contacting the medical centers. The ones who were suspected of a disease were further investigated at Sivas Cumhuriyet University Medical Faculty, Family Medicine Outpatient unit. For each disease a disease related history, physical examination, eye examination and pathergy test for BD were performed when needed. Results: 985 students, 978 mothers, 953 fathers and 1876 relatives (4792 in total) were included in the study. Only 30 (0.6%) of the sample was diagnosed with FMF, and 3 (%0.06) was diagnosed with BD. One of them had concomitant FMF diagnosis. Conclusion: The prevalence of FMF in Sivas is higher than Turkey's prevalence; however, BD prevalence was found very low. According to these findings, it is not easy to conclude that these two diseases share a similar background of pathogenesis. Disclosure of Interests: None declared