SAT0085 Relationship between serum calprotectin, disease activity parameters and the 7-joint ultrasound score in rheumatoid arthritis. (12th June 2018) - Torgutalp, M.
Abstract : Background: Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity. Objectives: In this study we aimed to investigate whether calprotectin is a better biomarker than known inflammation markers forpredicting clinical activity and ultrasound parameters in patients with RA. Methods: A total of 80 RA patients were underwent to clinical (swollen joint count, tender jointcount, disease activity score-DAS28, simplified disease activity index-SDAI and clinical disease activity index-CDAI) and ultrasound (German US7) examination. Correlation ofclinical, laboratory and ultrasound measures wereanalyzed using Spearman'scorrelation coefficient.The RA patients were divided into two subgroups according to their DAS28-ESR (erythrocyte sedimentation rate) score; group 1 (DAS-28 ≤3.2 remission and low activity), group 2 (DAS28 >3.2 moderate and high activity), respectively. Thirty healthy controls were simultaneously studied. Results: The serum calprotectin levels of the RA patients were significantly higher than those of healthy controls (96.3±45.9, 54.7±50.0, respectively; p<0.001). Distribution of age (years; 57.2±9.6, 53.9±10.5, respectively; p=0.115) and sex (female; 78.8%, 70%, respectively, p=0.336) between these groups were similar.The clinical, laboratory and ultrasound characteristics of the patients are shown in table 1. The calprotectin levels were 74.8±45.5 in group 1 (n=37) and 114.7±37.9 in group 2 (n=43) (p<0.001).The association between calprotectin and scores of DAS28-ESR are shown in figure 1A. Serum calprotectin was significantly associated with DAS28-ESR, DAS28-CRP (C-reactive protein), SDAI, CDAI, ESR, CRP and US7 parameters. We also found a moderate to strong correlation of US7 score with DAS28-ESR, DAS28-CRP, SDAI, CDAI, CRP and ESR (table 2).The correlation between calprotectin and US7 is shown in figure 1B. Conclusions: The results of our study support an additional role of calprotectin in assessing inflammatory activity in patients with RA.Therefore, the combination of serum calprotectinl evels and the US7 score could be a simple and practical assessment approach for detection of RA disease activity. Disclosure of Interest: None declared