Synthesis of Dihydro‐2‐oxopyrrole (DPO) Building Blocks Catalyzed by Potassium Carbonate. Issue 42 (7th November 2019)

• Record Type: Journal Article
• Authors: Zhang, Yan‐Shun; Gui, Hou‐Ze; Wei, Yin; Shi, Min
• Is Part Of: European journal of organic chemistry. Issue 42(2019)
• Page Start: 7179
• Page End: 7185
• Publication Date: 2019-11-07
• Subjects: Cycloaddition -- Homogeneous catalysis -- Nitrogen heterocycles -- Synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201901504
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A dimerization and cyclization cascade reaction of 2‐sulfonaminoacrylates catalyzed by K2 CO3 provides dihydro‐2‐oxopyrrole (DPO) derivatives. This straightforward and atom‐economic transformation features a simple experimental operation with easily available starting materials, a broad substrate scope as well as good functional group tolerance. The desired DPO building blocks are obtained in moderate to good yields. Abstract : We have disclosed a novel and efficient dimerization and cyclization cascade reaction of 2‐sulfonaminoacrylate derivatives catalyzed by K2 CO3 to synthesize dihydro‐2‐oxopyrroles (DPO) in moderate to good yields in one step.