Amide Bond Formation Strategies: Latest Advances on a Dateless Transformation. Issue 30 (4th May 2020)

• Record Type: Journal Article
• Authors: Massolo, Elisabetta; Pirola, Margherita; Benaglia, Maurizio
• Is Part Of: European journal of organic chemistry. Issue 30(2020)
• Page Start: 4641
• Page End: 4651
• Publication Date: 2020-05-04
• Subjects: Amidation -- Amides -- Catalysis -- Stoichiometric methods -- Synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202000080
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The synthesis of amides remains one of the most important transformations and it is one of the more frequently performed reactions. In the pharmaceutical industry, the formation of the amide group is pivotal and among the more important transformations in the design of the synthetic plan. This review presents an overview of only very recent contributions, published in the last three years, to highlight the latest progress in this "dateless" reaction, with a special focus on metal‐free methodologies. New, more efficient and/or greener stoichiometric methods, as well as catalytic strategies, have been discussed, either for the "classic" coupling approach between an amine and a carboxylic acid (or its activated equivalent) or for more innovative approaches, mainly involving oxidation procedures to generate amides starting from amines. Abstract : The amide function is unarguably of primary importance, being the constituent of natural and synthetic polymers and found in a wide variety of bioactive molecules. This review will discuss specifically the very recent advances in the area of amide synthesis, specially focusing on metal‐free strategies, based either on stoichiometric or on catalytic methods that were published in the last three years.