AB1337 Celiac disease and risk of sarcoidosis: a systematic review and meta-analysis. (12th June 2018)

• Record Type: Journal Article
• Authors: Wijarnpreecha, K.; Panjawatanan, P.; Lertjitbanjong, P.; Corral, J.E.; Ungprasert, P.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 1758
• Page End: 1758
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.4682
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Several epidemiologic studies have demonstrated that patients with celiac disease may be at an increased risk of devleoping sarcoidosis. However, the data on this risk remain inconsistent. Objectives: To compare the risk of developing sarcoidosis between patients with celiac disease and individuals without celiac disease. Methods: A literature review was performed using MEDLINE and EMBASE database from inception to December 2017. Studies that compared the risk of sarcoidosis among patients with celiac disease versus those without celiac disease were included. The inclusion criteria were as follows: 1 case-control, cross-sectional or cohort studies that investigated the risk of sarcoidosis among patients with celiac disease compared with individuals without celiac disease and 2 odds ratios (OR), relative risks (RR), hazard ratios (HR) or standardised incidence ratios (SIR) with 95% confidence intervals (CI) or sufficient raw data to calculate these ratios were provided. Study eligibility was independently determined by 3 investigators. Differences in the determination of study eligibility were resolved by mutual consensus. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Results: Of 375 retrieved studies, 4 studies (2 case-control studies and 2 cohort studies) with 6 93 639 participants met our eligibility criteria and were included in analysis. We found a higher risk of sarcoidosis among patients with celiac disease compared with individuals without celiac disease with the pooled OR of 7.16 (95% CI, 1.48–34.56). The statistical heterogeneity of this study was high (I 2= 95%). Funnel plot was relatively symmetric and did not suggest the presence of publication bias in favour of positive studies. Conclusions: This systematic review and meta-analysis found a significantly higher risk of sarcoidosis among patients with celiac disease. Disclosure of Interest: None declared