AB0565 Changes in health related quality of life in renaissance cohort of russian patients with systemic lupus erythematosus. (12th June 2018)

• Record Type: Journal Article
• Authors: Aseeva, E.; Vorobyova, L.; Soloviev, S.; Koilubaeva, G.; Glukhova, S.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 1437
• Page End: 1437
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.1663
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: The Lupus Quality of Life (LupusQol) is recommended to assess health related quality of life (HRQOL) in systemic lupus erythematosus (SLE). Objectives: The aim of the current study was to assess HRQOL in the first year observation in cohort of patients with systemic lupus erythematosus in Russian Federation (RENAISSANCE). Methods: The LupusQoL-Russian was administered to a cohort of 128 Russian patients affected with SLE at baseline and follow up visit (in 12 months). Disease activity was evaluated by the SLE disease activity Index-2000 (SLEDAI-2K), and chronic damage by the Systemic Lupus International Collaborating Clinics Damage Index score (SDI) at baseline and follow up visit. Results: 128 patients (118 (92%) women; aged 33, 02±11, 04 years, mean disease duration 100, 0±84, 3 months) were included. At baseline mean SLEDAI 2K was 11, 2±8, 5; mean SDI – 1, 3±1.6, mean daily prednisolone 16, 8±10, 9 mg/day). For 12 months all patients received standard therapy according SLEDAI 2K and their clinical manifestations (prednisolone 100%, Hydroxychloroquine 72, 4%, Mycophenolate mofetil 25%, Cyclophosphamide 17%, Azathioprine 12, 5%, Rituximab 27, 3%, belimumab 12, 5% pts). At follow up visit SLEDAI 2K score significantly improved up to 6, 94±6, 93 (p<0, 000029), SDI significantly worse up to 1, 7±1, 9 (p<0, 04), mean daily prednisolone significantly reduced up to 12, 2±7, 3 mg\day(p<0, 04). All 8 subscales LupusQol showed improvement in the 12 months versus baseline (table 1). Spearmen's correlation with SlEDAI 2K was obtained for Physical health (r=-0, 13), Pain (r=-0, 16), Planning (r=-0, 21), Intimate relationship(r=-0, 17) Burden to others(r=-0, 16), emotional health (r=-0, 13), Body image (r=-0, 21). Conclusions: The LupusQoL-Russian is sensitive to change in SLE patients with active SLE. The HRQOL correlated with disease activity, daily prednisolone and biologic. Disclosure of Interest: None declared