EFFECTS OF 3 MONTH COMBINED THERAPY WITH PERINDOPRIL AND INDAPAMIDE ON ENDOTHELIAL FUNCTION AND ARTERIAL STIFNESS IN OBESE HYPERTENSIVE WOMEN IN PERIMENOPAUSE. (April 2021)

• Record Type: Journal Article
• Authors: Danilogorskaya, Yulia; Zheleznykh, Elena; Privalova, Ekaterina; Belenkov, Yuriy; Kozhevnikova, Maria; Shchendrygina, Anastasia; Shakaryants, Gayane; Zektser, Vita
• Is Part Of: Journal of hypertension. Volume 39(2021)e-Supplement 1
• Publication Date: 2021-04
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000747032.24922.90
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract: Objective: To evaluate effects of 3-month combined therapy with Perindopril 10 mg and Indapamide 2.5 mg on endothelial function and arterial stiffness in obese hypertensive women in perimenopause. Design and method: Fifty perimenopause women with EAH and Obesity were enrolled in the study (average age 48, 5 (40, 75;48, 00) years old; average body mass index 31, 6 (31, 2; 32, 7) kg/sqm), SBP 139, 0 (137, 8;146, 3) mm Hg., DBP 84 (78, 8;89, 0) mm Hg. Investigation of endothelial function and arterial stiffness based on the pulse wave contour analysis and reactive hyperemia test ("Angioscan-01" device used) was conducted before and after 3 month treatment with 10 mg/day perindopril A and 2, 5 mg/day indapamide. The following parameters were evaluated: SI (stifness index), PS (phase shift) which caraterise structural and functional changes in large arteries and RI (resistance index), IO (occlusion index) which caracterise structural and functional changes in arteriols. Results: After 3-month combined treatment with 10 mg/day perindopril A and 2.5 mg/day indapamide significant decrease of SBP and DBP were observed: SBP from 139, 0 (137, 8;146, 3) mm Hg. to 123.0 (120, 75;128, 75), DBP from 84 (78, 8;89, 0) mm Hg. to 75, 5 (70;81, 5) mm Hg (p < 0.05); while SI significantly decrease from 9, 4 (8, 58;11, 33) m/s to 8, 4 (8, 0;9, 23) m/s (p < 0.05); as well as RI from 35, 0 (31, 0;48, 5) to 30 (26, 75; 34, 25)% (p < 0.05); SF significantly increased up to 8, 90 (7, 4;10, 02)ms from 7, 45 (6, 55;9, 15)ms (p < 0.05), as well as IO up to 1, 85 (1, 7;2, 1) from 1, 6 (1, 3;1, 9) Conclusions: 3-month therapy with perindopril A 10 mg/day and 2, 5 mg/day indapamide was associated with not only significat decrease of SBP and DBP but significant improving of endothelial function and structural parameters in large muscular arteries (increase of phase shift between channels, decrease of stiffness of large arteries) as well as in arteriols (decrease of RI and increase of IO).