DECREASED BLOOD PRESSURE AND INCREASED HEART RATE IN WOMEN WITH BREAST CANCER AFTER COMBINED CHEMOTHERAPY LEADS TO PSEUDO-POSITIVE CHANGES IN ARTERIAL STIFFNESS AND PULSE WAVE. (April 2021)

• Record Type: Journal Article
• Authors: Zairova, Alsu; Rogoza, Anatoly; Avaljan, Ani; Oshchepkova, Elena; Zheleznova, E
• Is Part Of: Journal of hypertension. Volume 39(2021)e-Supplement 1
• Publication Date: 2021-04
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000746036.65325.68
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: The aim of the study was to study the effect of combined chemotherapy in women with breast cancer (BC) on arterial stiffness and pulse wave by ultrasound examination of the common carotid artery (CCA) using echo tracking technology Design and method: 40 women with triple negative breast cancer aged 27 to 75 years (47.5 ± 12.0) were examined initially and after chemotherapy with the inclusion of anthracyclines (doxorubicin), taxanes (paclitaxel) and platinum derivatives (cisplatin). Arterial stiffness parametres (beta-stiffness index, Ep-elastic modulus, AC-arterial compliance, PWV-pulse wave velocity) and AI – augmentation index were studied in the distal CCA at a distance of 2 cm from bifurcation on an Aloka ProSound alrha7 ultrasound machine using echo tracking technology. Results: After combined chemotherapy the parameters beta-index, Ep, PWV not significantly changed (9, 3 ± 4, 3 vs 8, 9 ± 4, 5, p = 0, 63;128, 73 ± 65, 9 vs 119, 0 ± 69, 5 kPa, p = 0, 29; 6, 7 ± 1, 5 vs 6, 3 ± 1, 5 m/s, p = 0, 24 respectively). Statistically significant decrease in AI from 14, 5 ± 11, 3 to 11, 1 ± 10, 6% (p = 0, 009) and an increase in AC from 0, 72 ± 0, 25 to 0, 87 ± 0.3 mm2 /kPa (p = 0, 004) were demonstrated as well as decrease in systolic blood pressure (SBP) from 129, 5 ± 14, 0 to 118, 5 ± 14, 5 mm Hg (p = 0, 0001) and an increase in heart rate from 67, 9 ± 10, 7 to 76, 6 ± 12, 1 bpm (p = 0, 0004), lower the level of hemoglobin from 129, 6 ± 20, 4 to 102, 2 ± 16, 3 g/ l (p = 0, 00001) and red blood cells from 4, 7 ± 0, 4 to 3, 3 ± 0, 6 1012 / l(p = 0, 00001). SBP levels decreased both in women with AH (n = 12) who received anti-hypertensive therapy – from 146, 5 ± 9, 9 to 130, 0 ± 14, 6 mm Hg (p < 0, 01), and in eutonic women (n = 28) who received no antihypertensive treatment – from 122, 2 ± 7, 6 to 115, 4 ± 8.3 mm Hg (p = 0, 002). Conclusions: In women with breast cancer in the early period after combined chemotherapy with the inclusion of anthracyclines (doxorubicin), taxanes (paclitaxel) and platinum derivatives (cisplatin), there were no increased stiffness of the common carotid artery. Pseudo-positive changes in the form of an increase in the extensibility of the vascular wall and a decrease in the augmentation index are explained by general hemodynamic changes in the form of a decrease in the SBP, an increase in heart rate, as well as anemia during chemotherapy.