AB0288 Levels of metalloproteinase-3 (MMP-3) correlate better with clinical disease activity index (CDAI) and simplified disease activity index (SDAI) than standard disease assessment score (DAS-28). (12th June 2018)

• Record Type: Journal Article
• Authors: Vega, O.; Calvo, Y.; Torres, Z.; Gamboa, R.; Flores, S.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 1323
• Page End: 1323
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.5289
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: The MMP-3 is a matrixin calcium-dependent zinc-containing; the major expressed in rheumatoid synovial tissue; with essential role in the degradation of both aggrecan and collagen fibrils. Objectives: The aim was to evaluate the correlation of MMP3 levels with assessment scores of RA activity. Methods: 109 patients with RA as per the 2010 ACR/EULAR criteria were included in the prospective Study ALTRA. Patients were divided into groups of early arthritis active, established arthritis active, and remission with conventional remissive or biological remissive. The levels of MMP3 and activity scores: DAS28-ERS, DAS28-CPR, SDAI and SDAI were on the basis of predefined cut-offs. The correlation was determined with the Pearson Test for parametric variables and the Spearman Test for non-parametric variables. Results: The levels of MMP3 in patients with early RA Vs established were 63.2 and 39.9 U/ml, p<0.021 respectively. MMP3 levels of patients with activity measured by DAS28-ESR were 62.9 in the active and 35.2 U/ml in remission, p<0.000. The correlation between serum levels of MMP3 and DAS28-ERS was 0.21 (p<0.25), with DAS28-CRP 0.27 (p<0.004); CDAI 0.26 (p<0.06) and with SDAI 0.35 (p<0.002). Conclusions: Elevated MMP3 levels indicate state of disease activity; besides the addition in the expression of the collagen damage. This finding may help in making decisions in clinical practice. References: [1] Ohrndorf S, Fischer IU, Kellner H, Strunk J, Hartung W, Reiche B, et al. Reliability of the novel 7-joint ultrasound score: results from an inter- and intraobserver study performed by rheumatologists. Arthritis Care Res (Hoboken)2012;64(8):1238–43. [2] Houseman M, Potter C, Marshall N, Lakey R, Cawston T, Griffiths I, et al. Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up. Arthritis Res Ther2012;14(1):R30. [3] Moller I, Janta I, Backhaus M, Ohrndorf S, Bong DA, Martinoli C, et al. The 2017 EULAR standardised procedures for ultrasound imaging in rheumatology. Ann Rheum Dis. 2017;76(12):1974–9. [4] Siddiqui IJ, Luz J, Borg-Stein J, O'Connor K, Bockbrader M, Rainey H, et al. The Current State of Musculoskeletal Ultrasound Education in Physical Medicine and Rehabilitation Residency Programs. PM R. 2016;8(7):660–6. [5] Willemze A, Toes RE, Huizinga TW, Trouw LA. New biomarkers in rheumatoid arthritis. Neth J Med. 2012;70(9):392–9. Acknowledgements: Lic. Marcela Tafur Disclosure of Interest: None declared