High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer. (5th November 2021)

• Record Type: Journal Article
• Authors: Cui, Yun-Qian; Meng, Fei; Zhan, Wen-Li; Dai, Zhou-Tong; Liao, Xinghua
• Other Names: Ergün Sercan Academic Editor.
• Is Part Of: BioMed research international. Volume 2021(2021)
• Publication Date: 2021-11-05
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2021/5282894
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment.