Against all odds: anti-IgE for intrinsic asthma?. Issue 1 (24th May 2013)

• Record Type: Journal Article
• Authors: Lommatzsch, Marek; Korn, Stephanie; Buhl, Roland; Virchow, Johann Christian
• Is Part Of: Thorax. Volume 69:Issue 1(2014)
• Page Start: 94
• Page End: 96
• Publication Date: 2013-05-24
• Subjects: Asthma -- Asthma Mechanisms -- Asthma Pharmacology; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2013-203738
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.