Clinical Reasoning: A 59-Year-Old Man With Progressive Proximal Weakness Since Childhood. (16th November 2021)

• Record Type: Journal Article
• Authors: Davalos, Long; Janecek, Jacqueline; Fudym, Yelena; McKeever, Paul; Callaghan, Brian C.
• Is Part Of: Neurology. Volume 97:Number 20(2021)
• Page Start: 958
• Page End: 963
• Publication Date: 2021-11-16
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000012488
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : A 59-year-old man presented with slowly progressive weakness. During childhood, he had difficulty climbing stairs. At age 30 years, he noted difficulty getting out of a chair or standing up from the floor without using his arms. At age 48 years, he started having 3–4 falls per year. He denied orthopnea and dyspnea. He had well-controlled hypothyroidism and hyperlipidemia. Medications included levothyroxine and niacin, and he denied the use of statins, fibrates, steroids, and alcohol intake. His parents (unrelated), sister, and 2 sons (aged 16 and 18 years) had no weakness. His maternal grandfather had leg weakness with difficulty climbing stairs around age 30 years and was using a wheelchair by age 60 years.