Systemic lupus erythematosus/ANCA-associated vasculitis overlap: An explanation for atypical lupus manifestation. (April 2022)

• Record Type: Journal Article
• Authors: Botero B, Juan D; Bernal-Macías, Santiago; Celis P, Carlos A; Lasso A, Javier I; Rodríguez, Jorge; Arias Álvarez, Liliana; Gonzalez, Catalina; Contreras, Kateir M; Fernández-Ávila, Daniel G
• Is Part Of: Lupus. Volume 31:Number 4(2022)
• Page Start: 495
• Page End: 499
• Publication Date: 2022-04
• Subjects: Systemic Lupus Erythematosus -- Granulomatosis with Polyangiitis -- ANCA-Associated Vasculitis -- Interstitial Lung Diseases; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/09612033221084519
• Languages: English
• ISSNs: 0961-2033

Abstract

The coexistence of systemic lupus erythematosus (SLE) and ANCA-associated vasculitis (AAV) as an overlapping syndrome is not common. Here, we report a case of a 33-year-old woman, with recent SLE diagnosis due to skin, kidney, articular, and immunologic compromise, in whom a chest CT scan showed bilateral nodules, consolidations, and tree-in-bud pattern; thoracoscopic lung biopsy revealed diffuse non-caseating granulomas, without other features of sarcoid, organizing pneumonia, or hypersensitivity pneumonitis with high positive p-ANCA titers. Overlap between SLE and AAV was a possible explanation for lupus granulomatous pneumonitis, and for this reason, a multidisciplinary meeting was held to evaluate complex patients with interstitial lung diseases patients.