Neural processing of nouns and verbs in spontaneous speech of patients with schizophrenia. (30th December 2021)

• Record Type: Journal Article
• Authors: Hahn, Wiebke; Domahs, Frank; Straube, Benjamin; Kircher, Tilo; Nagels, Arne
• Is Part Of: Psychiatry research. Volume 318(2021)
• Publication Date: 2021-12-30
• Subjects: IFG, fMRI, transitivity; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2021.111395
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: Neural processing of nouns and verbs in schizophrenia. Activation differences in spontaneous speech in the left IFG. Correlation with psychopathological assessments. Abstract: Previous fMRI-studies investigating the production of nouns and verbs in healthy participants reported predominantly activation in the left inferior frontal gyrus (IFG) for both classes of words with increased neural responses for verbs. To date, comparable imaging data for spontaneous speech in patients with schizophrenia is missing. These results are novel and may contribute to understand the neural basis of noun and verb production in a "natural" environment. Fifteen patients with schizophrenia and fifteen healthy control participants described pictures for one minute each while BOLD signal changes were measured with fMRI. In an event-related design, activations related to noun and verb production were extracted in the imaging analysis. Imaging results revealed increased activation for nouns and decreased activation for verbs in the left IFG in the patients. A post-hoc analysis revealed that patients produced significantly more transitive verbs which were negatively associated with activation in the left IFG. We conclude that a subtle linguistic processing deficit in schizophrenia may lead to an increased use of transitive as compared to intransitive verbs in connected speech and to a deviant pattern of brain activation related to the processing of verbs.