Two new ionones from the fresh roots of Rehmannia glutinosa. (December 2021)

• Record Type: Journal Article
• Authors: Chen, Xu; Cao, Yan-gang; Zhang, Yu-han; Zeng, Meng-nan; Ren, Ying-jie; Liu, Yan-ling; He, Chen; Fan, Xi-ling; Zheng, Xiao-ke; Feng, Wei-sheng
• Is Part Of: Phytochemistry letters. Volume 46(2021)
• Page Start: 114
• Page End: 118
• Publication Date: 2021-12
• Subjects: Scrophulariaceae -- Rehmannia glutinosa -- Ionones -- Renoprotective activities; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2021.10.005
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new ionones were isolated from the fresh roots of Rehmannia glutinosa . The structures were established based on spectroscopic data and ECD spectra analyses. Compounds 1 and 2 exhibited moderate protective effects against LPS-induced damage to NRK-52e cells. Abstract: Two new ionones, frehmaglutin F (1) and frehmaglutin G (2), along with eight known compounds (3 –10 ) were isolated from the EtOAc extract of the fresh roots of Rehmannia glutinosa . All the structures were established by interpretation of the MS and NMR spectroscopic data. The absolute configurations of the new compounds were determined by comparing their experimental and calculated ECD spectra. The protective effects of all compounds against LPS-induced normal rat kidney tubule epithelioid (NRK-52e) cells were evaluated by MTT and RTCA assay. The results indicated that compounds 4 and 6 –8 exhibited moderate protective activities with the EC50 values of 10.2–40.7 μ M.