A case report of testicular diffuse large B-cell malignant lymphoma with cutaneous metastasis: A rare entity. (November 2021)

• Record Type: Journal Article
• Authors: Hermi, Amine; Bibi, Mokhtar; Rahoui, Moez; Chelly, Beya; Rhouma, Sami Ben; Nouira, Yassine
• Is Part Of: International journal of surgery case reports. Volume 88(2021)
• Publication Date: 2021-11
• Subjects: Testicular -- Lymphoma -- Metastasis -- Skin -- Orchidectomy -- Case report; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2021.106519
• Languages: English
• ISSNs: 2210-2612

Abstract

Abstract: Introduction and importance: Primary testicular lymphoma (PTL) is a variety of extra-nodal lymphoma taking origin from testis. It accounts 5% of all testicular tumors. Metastasis may occur in contralateral testis, bone, central nervous system and rarely in skin. Herein, we present the case of testicular diffuse large B-cell malignant lymphoma with cutaneous metastasis. Case presentation: A 60-year-old male presented with swollen painless solid right testis, with homolateral inguinal nodes. Testicular tumors markers were within normal range. Right radical orchidectomy was performed. Histopathological examination concluded to the diagnosis of Diffuse Large B Cell Lymphoma. Four weeks later, the patient presented alteration of general condition and multiples cutaneous centimetric lesions located in the right inguinal region. Biopsy of this lesion confirmed the diagnosis of metastases from the testicular lymphoma. The patient deceased three days later, before starting further treatment. Clinical discussion: Primary testicular lymphoma is a rare variety of testicular tumors. The prognosis is poor. Metastasis may occur in different sites such as contralateral testis, central nervous system, and skin. The prognosis is usually poor in the rare case of cutaneous metastasis. Conclusion: Primary testicular tumor is an aggressive rare variety of testicular tumors with poor prognosis. Cutaneous metastasis is rarely reported. Cutaneous lesions should be explored and suspected to be malignant. Early treatment with rapid multidisciplinary management is the key for adequate approach. Highlights: Primary testicular lymphoma is rare, aggressive testicular tumor. Skin metastasis is extremely rare, and if present, compromises the prognosis. Diagnosis may be comforted by 18F-PET-CT. Orchidectomy followed by chemotherapy is the recommended therapeutic options.