Evaluation of resveratrol-doped adhesive with advanced dentin bond durability. (November 2021)

• Record Type: Journal Article
• Authors: Guo, Rui; Peng, Wenan; Yang, Hongye; Yao, Chenmin; Yu, Jian; Huang, Cui
• Is Part Of: Journal of dentistry. Volume 114(2021)
• Publication Date: 2021-11
• Subjects: Dental adhesive -- Dentin bonding -- Bond durability -- Resveratrol -- Biofilm; Dentistry -- Periodicals; Dentistry -- Periodicals; Dentisterie -- Périodiques; Electronic journals; 617.6005
• DOI: 10.1016/j.jdent.2021.103817
• Languages: English
• ISSNs: 0300-5712

Abstract

Abstract: Objectives: This paper aimed to evaluate the influence of resveratrol-doped adhesive on the durability and antibiofilm capability of dentin bonding. Methods: Experimental adhesives were prepared by incorporating resveratrol into a universal adhesive at concentrations of 0 (control), 0.1, 1, and 10 mg/mL. The microtensile bond strength, fracture modes, and adhesive–dentin interface nanoleakage were assessed after 24 h of water storage, 10, 000 times of thermocycling or 1-month of collagenase ageing. Relevant antibiofilm capability on Streptococcus mutans ( S. mutans ), in situ zymography, degree of conversion, and cytotoxicity of resveratrol-doped adhesives were also determined. Results: Irrespective of thermocycled or collagenase ageing, the resveratrol-doped adhesive (1 mg/mL) maintained the bond strength and reduced the nanoleakage expression. Meanwhile, the inhibitory ability on endogenous protease activity and S. mutans biofilm formation with acceptable biocompatibility were obtained. Conclusions: This study suggested that the resveratrol-doped adhesive achieved effective improvement on dentin bond durability and secondary caries management. Clinical significance: The application of the resveratrol-doped adhesive indicates promising benefits to increase the lifetime of composite restorations.