Chronic rhinosinusitis: microbiology and treatment of acute exacerbations in patients after endoscopic surgery. Issue 12 (6th December 2021)

• Record Type: Journal Article
• Authors: Woźniak, A; Nowak, K; Wnuk, J; Kaczmarczyk, J; Król, P; Stręk, P; Składzień, J; Szaleniec, J
• Is Part Of: Journal of laryngology & otology. Volume 135:Issue 12(2021)
• Page Start: 1088
• Page End: 1093
• Publication Date: 2021-12-06
• Subjects: Sinusitis -- Bacteria -- Microbiota -- Anti-Bacterial Agents; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1017/S0022215121002759
• Languages: English
• ISSNs: 0022-2151

Abstract

Abstract: Objective: Antibiotics are the mainstay of therapy for acute exacerbation of chronic rhinosinusitis. However, no treatment guidelines exist. Most clinicians follow the recommendations for acute bacterial rhinosinusitis, usually caused by Haemophilus influenzae, Streptococcus pneumoniae or Moraxella catarrhalis, and treat with amoxicillin or amoxicillin-clavulanate. Method: Medical data of 810 patients who had undergone endoscopic sinus surgery were analysed retrospectively. The results of bacterial cultures and treatment course were assessed in 152 patients who presented with acute exacerbation of chronic rhinosinusitis within 6 months of endoscopic sinus surgery. Results: The most common bacterial species present were Staphylococcus aureus (36 per cent), Pseudomonas aeruginosa (13 per cent) and Escherichia coli (11 per cent). Most of the isolates showed resistance or intermediate sensitivity to amoxicillin-clavulanate. Targeted antibiotic therapy was significantly more effective than empiric therapy (71 per cent versus 42 per cent). The most effective antibiotics were fluoroquinolones. Conclusion: Acute exacerbation of chronic rhinosinusitis shows different microbiology than acute bacterial rhinosinusitis and requires a different therapeutic approach. It is optimally treated with culture-directed antibiotic therapy.