Cohort study: "Outcomes of kidney transplantation in patients with prosthetic heart valves". (19th October 2021)

• Record Type: Journal Article
• Authors: Ouahmi, Hajar; Moceri, Pamela; Zorzi, Kevin; Albano, Laetitia; Durand, Matthieu; Karimi, Fatimaezzahra; Morelon, Emmanuel; Buron, Fanny; Le Quintrec, Moglie; Pernin, Vincent; Ladriere, Marc; Girerd, Sophie; Dantal, Jacques; Loupy, Alexandre; Couzi, Lionel; Ferrari, Emile; Esnault, Vincent; Merville, Pierre; Legendre, Christophe; Giral, Magali; Sicard, Antoine
• Other Names: Badet Lionel investigator.; Brunet Maria investigator.; Buron Fanny investigator.; Cahen Rémi investigator.; Codas Ricardo investigator.; Daoud Sameh investigator.; Dubois Valérie investigator.; Fournie Coralie investigator.; Grégoire Arnaud investigator.; Koenig Alice investigator.; Lévi Charlène investigator.; Morelon Emmanuel investigator.; Pouteil‐Noble Claire investigator.; Rabeyrin Maud investigator.; Rimmelé Thomas investigator.; Thaunat Olivier investigator.; Abdo Nicolas investigator.; Delmas Sylvie investigator.; Le Quintrec Moglie investigator.; Pernin Vincent investigator.; Perrochia Hélène investigator.; Serre Jean‐Emmanuel investigator.; Szwarc Ilan investigator.; Aarnink Alice investigator.; Alla Asma investigator.; Eschwege Pascal investigator.; Frimat Luc investigator.; Girerd Sophie investigator.; Hubert Jacques investigator.; Kormann Raphaël investigator.; Ladriere Marc investigator.; Lagrange François investigator.; Laurain Emmanuelle investigator.; Lecoanet Pierre investigator.; Lemelle Jean‐Louis investigator.; Mannuguerra Anthony investigator.; Mazeaud Charles investigator.; Peres Michael investigator.; Blancho Gilles investigator.; Branchereau Julien investigator.; Cantarovich Diego investigator.; Chapelet Agnès investigator.; Dantal Jacques investigator.; Deltombe Clément investigator.; Figueres Lucile investigator.; Garandeau Claire investigator.; Giral Magali investigator.; Gourraud‐Vercel Caroline investigator.; Hourmant Maryvonne investigator.; Karam Georges investigator.; Kerleau Clarisse investigator.; Meurette Aurélie investigator.; Ville Simon investigator.; Kandell Christine investigator.; Moreau Anne investigator.; Renaudin Karine investigator.; Cesbron Anne investigator.; Delbos Florent investigator.; Walencik Alexandre investigator.; Devis Anne investigator.; Albano Laetitia investigator.; Karimi Fatimaezzahra investigator.; Sicard Antoine investigator.; Ouahmi Hajar investigator.; Chevallier Daniel investigator.; Tibi Brannwel investigator.; Durand Matthieu investigator.; Ahallal Younes investigator.; Amrouche Lucile investigator.; Anglicheau Dany investigator.; Aubert Olivier investigator.; Bererhi Lynda investigator.; Legendre Christophe investigator.; Loupy Alexandre investigator.; Martinez Frank investigator.; Sberro‐Soussan Rébecca investigator.; Scemla Anne investigator.; Tinel Claire investigator.; Zuber Julien investigator.; Glotz Denis investigator.; Lefaucheur Carmen investigator.;
• Is Part Of: Transplant international. Volume 34:Number 11(2021)
• Page Start: 2297
• Page End: 2304
• Publication Date: 2021-10-19
• Subjects: biological heart valve -- cardiac valve replacement -- end‐stage kidney disease -- kidney transplantation -- mechanical heart valve -- prosthetic heart valve; Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/tri.14008
• Languages: English
• ISSNs: 0934-0874

Abstract

Summary: The number of kidney transplant candidates with prosthetic heart valves (PHVs) is increasing. Yet, outcomes of kidney transplantation in these patients are still unclear. This is the first report of post‐transplant outcomes in patients with PHVs at time of kidney transplantation. We conducted a matched cohort study among recipients from the multicentric and prospective DIVAT cohort to compare the outcomes in patients with left‐sided PHVs at time of transplantation and a group of recipients without PHV matched according to age, dialysis time, initial disease, pretransplant DSA, diabetes, and cardiovascular events. Of 23 018 patients, 92 patients with PHVs were included and compared to 276 patients without PHV. Delayed graft function and postoperative bleeding occurred more frequently in patients with PHVs. Kidney graft survival was similar between groups. 5‐year overall survival was 68.5% in patients with PHV vs. 87.9% in patients without PHV [HR, 2.72 (1.57–4.70), P = 0.0004]. Deaths from infection, endocarditis, and bleeding were more frequent in patients with PHV. Mechanical valves, but not bioprosthetic valves, were independent risk factors for mortality [HR, 2.89 (1.68–4.97), P = 0.0001]. Patients with PHV have high mortality rates after kidney transplantation. These data suggest that mechanical valves, but not biological valves, increase risks of post‐transplant mortality. Abstract : Patients with PHV have high mortality rates after kidney transplantation. Mechanical valves, but not biological valves increase risks of post‐transplant mortality.