Emerging Materials and Technologies with Applications in Flexible Neural Implants: A Comprehensive Review of Current Issues with Neural Devices. Issue 47 (29th May 2021)

• Record Type: Journal Article
• Authors: Cho, Younguk; Park, Sanghoon; Lee, Juyoung; Yu, Ki Jun
• Is Part Of: Advanced materials. Volume 33:Issue 47(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-29
• Subjects: biointegrated electronics -- flexible electronics -- neural implants; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202005786
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Neuroscience is an essential field of investigation that reveals the identity of human beings, with a comprehensive understanding of advanced mental activities, through the study of neurobiological structures and functions. Fully understanding the neurotransmission system that allows for connectivity among neuronal circuits has paved the way for the development of treatments for neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and depression. The field of flexible implants has attracted increasing interest mainly to overcome the mechanical mismatch between rigid electrode materials and soft neural tissues, enabling precise measurements of neural signals from conformal contact. Here, the current issues of flexible neural implants (chronic device failure, non‐bioresorbable electronics, low‐density electrode arrays, among others are summarized) by presenting material candidates and designs to address each challenge. Furthermore, the latest investigations associated with the aforementioned issues are also introduced, including suggestions for ideal neural implants. In terms of the future direction of these advances, designing flexible devices would provide new opportunities for the study of brain–machine interfaces or brain–computer interfaces as part of locomotion through brain signals, and for the treatment of neurodegenerative diseases. Abstract : Flexible implants have attracted increasing interest, mainly to overcome the mechanical mismatch between rigid materials and soft neural tissues, enabling precise measurements of neural signals from conformal contact. The current issues of flexible neural implants are summarized by presenting material candidates and designs to address challenges. Furthermore, the latest investigations associated with each issue are also introduced.