Anticancer activity of oleiferoside B involving autophagy and apoptosis through increasing ROS release in MCF-7 cells and SMMC-7721 cells. Issue 22 (18th November 2021)

• Record Type: Journal Article
• Authors: Feng, Suxiang; Zha, Zhengxia; Wang, Zhe; Yang, Ping; Wu, Jiangping; Li, Xia; Xu, Qiongming; Liu, Yanli
• Is Part Of: Natural product research. Volume 35:Issue 22(2021)
• Page Start: 4865
• Page End: 4869
• Publication Date: 2021-11-18
• Subjects: Oleiferoside B -- autophagy -- apoptosis -- ROS; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1739039
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Oleiferoside B is a triterpenoid monomer compound, mainly isolated from roots of Camellia oleifera Abel, the underlying mechanism of its antitumour is not clear. In the present study, oleiferoside B potently inhibited SMMC-7721 and MCF-7 cells proliferation and cause cells apoptosis. In addition, it activated an autophagy-mediated cell death pathway, as indicated by the accumulated the ratio of LC3- II/LC3- I and inhibited apoptosis protein expression after pre-treatment with autophagy inhibitors 3-MA. Further studies showed that oleiferoside B-induced apoptosis and autophagy was attributed to ROS release. In vivo oleiferoside B (1.0, 0.5 mg/kg) effectively suppressed tumour growth. In conclusion, our finding reveals a novel mechanism of action of oleiferoside B in cancer cells via induction of apoptosis and autophagy through ROS generation. Therefore, our results provided new insight into the mechanism of the antitumour effect of oleiferoside B as a prospective therapeutic drug in the tumour. Graphical Abstract: