Alfa glucosidase inhibitory, anti inflammatory activities and a new furanocoumarin derivative of Ruellia tuberosa. Issue 22 (18th November 2021)

• Record Type: Journal Article
• Authors: Trinh, Pham Thi Nhat; Giang, Bach Long; Tuan, Nguyen Trong; Hang, Hoang Thi Thu; Thuy, Nguyen Thi Le; Tuan, Nguyen Ngoc; Dung, Le Tien
• Is Part Of: Natural product research. Volume 35:Issue 22(2021)
• Page Start: 4248
• Page End: 4255
• Publication Date: 2021-11-18
• Subjects: Furanocoumarin -- α-glucosidase inhibition -- anti inflammation -- Ruellia tuberosa; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1696790
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Rullia tuberosa L. is used for treatment of diabetes mellitus, anti-inflammation, etc. However, its hypoglycaemic and anti inflammatory activities has not been investigated so far. In the present study, the α-glucosidase inhibitory, anti inflammatory activities of the extract of this plant were investigated. Our results showed that the crude extract as well as ethyl acetate and methanol fractions showed α-glucosidase inhibitory activity with IC50 of 15.84, 4.73 and 8.27 µg/ml, respectively. In addition, the hexane and ethyl acetate fractions are capable of inhibiting LPS-induced NO production with IC50 of 17.41 and 23.95 µg/mL, respectively. From the ethyl acetate and methanol fractions, eight compounds, including isobargaptol 5-O-β-D-glucopyranoside (1 ), syringaresinol (2 ), catechin (3 ), pulmatin (4 ), stigmast-4-en-3-on (4 ), verbascoside (5 ), hydroxymethylfurfural (6 ), rutin (7 ), and homoplantaginin (8 ) were extracted and isolated. Their chemical structures were elucidated by spectroscopic method including MS, 1 D and 2 D- NMR and comparison with the literature values. Graphical Abstract: