Plantanone D, a new rare methyl-flavonoid from the flowers of Hosta plantaginea with anti-inflammatory and antioxidant activities. Issue 22 (18th November 2021)

• Record Type: Journal Article
• Authors: Yang, Li; Zhu, Yuye; He, Zhongwei; Zhang, Tingfang; Xiao, Zhixi; Xu, Ruoling; He, Junwei
• Is Part Of: Natural product research. Volume 35:Issue 22(2021)
• Page Start: 4331
• Page End: 4337
• Publication Date: 2021-11-18
• Subjects: Hosta plantaginea -- methyl-flavonoid -- plantanone D -- cyclooxygenase inhibition -- antioxidant; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1713121
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Flowers of Hosta plantaginea have been used for the treatment of inflammation-related diseases in traditional Chinese medicine with limited scientific validation. In the present work, we reported one new rare methyl-flavonoid, plantanone D (1 ) and one known compound 4-hydroxybenzoic acid (2 ) from the flowers of H. plantaginea . Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. To the best of our knowledge, the methyl-flavonoid skeleton have not been reported from any species in Liliaceae family, compound 2 was isolated from the genus Hosta for the first time. The anti-inflammatory activities against cyclooxygenases (COX-1 and COX-2) and antioxidant activities in vitro results revealed that 1 exhibited significant COX-1 inhibition and moderate COX-2 inhibition compared to the reference celecoxib. Additionally, 1 displayed significant antioxidant activity compared to the positive control L-ascorbic acid. Graphical Abstract: