Cytotoxicity of a new tirucallane derivative isolated from Stereospermum acuminatissimum K. Schum stem bark. Issue 22 (18th November 2021)

• Record Type: Journal Article
• Authors: Leutcha, Bosco Peron; Sema, Denis Kehdinga; Dzoyem, Jean Paul; Ayimele, Godfred Aponglen; Nyongbela, Kennedy D.; Delie, Florence; Alléman, Éric; Sewald, Norbert; Meli Lannang, Alain
• Is Part Of: Natural product research. Volume 35:Issue 22(2021)
• Page Start: 4417
• Page End: 4422
• Publication Date: 2021-11-18
• Subjects: Triterpene -- Stereospermum acuminatissimum -- cytotoxicity -- antiproliferative activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1723085
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new tirucallan derivative, leutcharic acid (1 ) was isolated from Stereospermum acuminatissimum stem bark together with the known compounds 3-oxo-22-hydroxyhopane (2 ), 3, 4-secotirucalla-4(28), 7, 24-trien-3, 21-dioic acid (3 ), 3-oxotirucalla-7, 24-dien-21-oic acid (7 ), lupeol (4 ), β -sitosterol (5 ) and stigmasterol (6 ). The structures of the isolated compounds were elucidated using 1 D and 2 D NMR spectroscopy in combination with literature data. To the best of our knowledge, this is the first report on the cytotoxic properties' constituents of S. acuminatissimum . Cytotoxicity of compounds 1 and 2 was assessed in vitro with the WST-1 assay on human lung adenocarcinoma A549 and THP-1 human monocytic leukaemia cell lines. Both compounds showed antiproliferative activity on the cancer cells. Compound 2 was more active against THP-1 with an IC50 value of 26.83 µM. The sensitivity of THP-1 cells to compounds 1 and 2 indicated that these compounds might be potential leads for anticancer agent development against leukaemia. Graphical Abstract: