Shoot aqueous extract of Manihot esculenta Crantz (cassava) acts as a protective agent against paracetamol-induced liver injury. Issue 22 (18th November 2021)

• Record Type: Journal Article
• Authors: Elshamy, Abdelsamed I.; El Gendy, Abd El-Nasser G.; Farrag, Abdel Razik H.; Hussein, Jihan; Mohamed, Nadia A.; El-Kashak, Walaa A.; Nardoni, Simona; Mancianti, Francesca; De Leo, Marinella; Pistelli, Luisa
• Is Part Of: Natural product research. Volume 35:Issue 22(2021)
• Page Start: 4724
• Page End: 4728
• Publication Date: 2021-11-18
• Subjects: Manihot esculenta -- antioxidant -- cassava shoot -- flavonoids -- hepatoprotection; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1712386
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Manihot esculenta Crantz (Euphorbiaceae), known as cassava, is a widely cultivated plant, considered one of the main sources of food in the tropical and subtropical regions of Africa and Asia. The aim of the present study was the evaluation of the antioxidant and anti-inflammatory effects of cassava shoot aqueous extract (CSAE) on liver injury induced by paracetamol and investigation of its effect on hyperhomocysteinemia. CSAE was administered to male albino rats classified into seven groups: control, treated, and prophylactic groups. A significant reduction in liver enzymes, malondialdehyde, and homocysteine were observed when compared to the paracetamol group, together with an increase in paraoxonase-1. Histopathological and histochemical results indicated that CSAE effectively ameliorate these parameters. Two main flavonol glycosides, quercetin 3- O -rutinoside and kaempferol 3- O -rutinoside, in addition to a minor myricetin 3- O -rutinoside, were identified in CSAE. CSAE showed a therapeutic potential against paracetamol-induced liver injury probably through antioxidant activity of its flavonol glycosides. Graphical Abstract: