Hesperozygis ringens (Benth.) Epling: a study involving extraction, chemical profiling, antioxidant and biological activity. Issue 22 (18th November 2021)

• Record Type: Journal Article
• Authors: Dolwitsch, Carolina B.; Pires, Fernanda B.; Frescura, Lucas M.; Prá, Valéria Dal; Rieffel, Roberta C.; Sagrillo, Michele R.; de Carvalho, Camilo A.; Mazutti, Marcio; Pizzutti, Ionara R.; da Rosa, Marcelo B.
• Is Part Of: Natural product research. Volume 35:Issue 22(2021)
• Page Start: 4709
• Page End: 4714
• Publication Date: 2021-11-18
• Subjects: Hesperozygis ringens -- ultrasound-assisted extraction -- supercritical fluid extraction -- antioxidant -- cytotoxicity -- genotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1710703
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Hesperozygis ringens is a plant of the Lamiaceae family which is restricted to the Southern region of Brazil. It is popularly used as an insecticide, but knowledge on it is very scarce. This study aimed to determine the chemical markers of H. ringens extracts obtained via ultrasound-assisted (UAE-EtOH) and supercritical fluid (SFE-CO2 ) extractions. UAE-EtOH and SFE-CO2 extracts were characterised by UPLC-MS and GC-MS, respectively. Both products had their antioxidant activity, cytotoxicity and genotoxicity evaluated. Twelve compounds were found in the UAE-EtOH extract, including phenolic acids and flavonoids; the SFE-CO2 extract contained terpenes and phytosterols. The UAE-EtOH extract showed a greater antioxidant activity. Neither extract presented cytotoxicity or genotoxicity against human mononuclear blood cells. Graphical Abstract: