Identification and antimicrobial properties of a new alkaloid produced by marine-derived Verrucosispora sp. FIM06-0036. Issue 22 (18th November 2021)

• Record Type: Journal Article
• Authors: Chen, Ming-Hong; Lian, Yun-Yang; Fang, Dong-Sheng; Chen, Li; Jia, Jia; Zhang, Wen-Long; Lin, Ru; Xie, Yang; Bi, Hong-Kai; Jiang, Hong
• Is Part Of: Natural product research. Volume 35:Issue 22(2021)
• Page Start: 4211
• Page End: 4217
• Publication Date: 2021-11-18
• Subjects: Actinomycete -- Verrucosispora -- antibiotics -- antimicrobial activity -- Helicobacter pylori; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1689498
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The actinomycete strain FIM06-0036 was isolated from marine sponge sample collected from the East China Sea and identified as Verrucosispora sp. based upon the results of 16S rRNA sequence analysis. One new alkaloid, 2-ethylhexyl 1H-imidazole-4-carboxylate (1 ), together with a known alkaloid butyl 1H-imidazole-4-carboxylate (2 ) was obtained from the fermentation products of this strain, the structures of compounds 1 and 2 were determined by their detailed analysis of 1 D, 2 D NMR and HR-ESI-MS data, along with literature data analysis. Compounds 1 and 2 were evaluated for their antimicrobial activity with MIC (minimum inhibitory concentration) values ranging from 8 to 256 μg · mL −1 against Helicobacter pylori, Klebsiella Pneumonia, Staphylococcus aureus and Enterococcus faecalis. Graphical Abstract: