Euphanoids A and B, two new lathyrane diterpenoids with nitric oxide (NO) inhibitory activity from Euphorbia kansuensis. Issue 22 (18th November 2021)

• Record Type: Journal Article
• Authors: Yan, Xue-Long; Fan, Run-Zhu; Sang, Jun; Xie, Xing-Lin; Tang, Gui-Hua; Yin, Sheng
• Is Part Of: Natural product research. Volume 35:Issue 22(2021)
• Page Start: 4402
• Page End: 4408
• Publication Date: 2021-11-18
• Subjects: Euphorbia kansuensis -- NO inhibitory activity -- lathyrane -- euphanoid; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1719491
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new lathyrane diterpenoids, euphanoids A and B (1 and 2 ), along with five known compounds (3 –7 ) were isolated from the roots of Euphorbia kansuensis . Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by single crystal X-ray diffraction. All of the isolates were screened for the inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 cells, and compounds 1 and 2 showed pronounced inhibition on NO production with IC50 values of 4.7 and 9.5 μM, respectively, being more active than the positive control, quercetin (IC50 = 10.8 μM). Graphical Abstract: