Oxazolomycins produced by Streptomyces glaucus and their cytotoxic activity. Issue 55 (28th October 2021)

• Record Type: Journal Article
• Authors: Mu, Yu; Jiang, Yi; Qu, Xiaodan; Liu, Bo; Tan, Junfeng; Li, Guiding; Jiang, Mingguo; Li, Liya; Han, Li; Huang, Xueshi
• Is Part Of: RSC advances. Volume 11:Issue 55(2021)
• Page Start: 35011
• Page End: 35019
• Publication Date: 2021-10-28
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra06182h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Six oxazolomycins (1–6 ) were isolated from the fermentation broth of a soil-borne bacterial strain, Streptomyces glaucus . Abstract : Six oxazolomycins (1–6 ) were isolated from the fermentation broth of a soil-borne bacterial strain, Streptomyces glaucus . The structures of the new compounds, oxazolomycins D–F (1–3 ) and glaucumycins A, B (6a /6b ), were elucidated by detailed spectroscopic data analysis. Oxazolomycins 1, 2, 4, and 5 demonstrated weak or modest cytotoxic activities against four human cancer cell lines, with IC50 values ranging from 10.6 ± 1.7 to 89.5 ± 6.6 μM (or >100 μM). Further study showed that 4 caused S phase cell cycle arrest in SMMC7721 cells through down-regulating the protein expression of cyclin A2, CDK2. Meanwhile, 4 induced apoptosis in SMMC7721 cells through down-regulating the protein levels of Bcl-2, up-regulating the levels of Bax, and activating the cleavage of caspase-3.