Facile synthesis and nematicidal activity evaluation of thiophosphinyl amide [(Pz)2P(S)NHR] and thiophosphonyl diamide [(Pz)P(S)(NHR)2] (Pz = 1, 3, 5-trimethylpyrazole, R = biphenyl derivatives). Issue 57 (10th November 2021)

• Record Type: Journal Article
• Authors: Chen, Xiao; Lu, Xiaogang; Liu, Haibo; Wang, Hongmei; Pei, Chengxin
• Is Part Of: RSC advances. Volume 11:Issue 57(2021)
• Page Start: 36250
• Page End: 36256
• Publication Date: 2021-11-10
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra06232h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A series of SDHI (succinate dehydrogenase inhibitor)-like thiophosphinyl amide [(Pz)2 P(S)NHR] and thiophosphonyl diamide [PzP(S)(NHR)2 ] compounds, where Pz = 1, 3, 5-trimethylpyrazole and N(H)R = derivatives of 2-aminobiphenyl, were synthesized via a facile two-step process. Some of their nematicidal activities towards Meloidogyne incogita are stronger than that of the amide analogue bixafen. Abstract : A series of thiophosphinyl amide [(Pz)2 P(S)NHR] and thiophosphonyl diamide [PzP(S)(NHR)2 ] compounds, where Pz = 1, 3, 5-trimethylpyrazole and N(H)R = derivatives of 2-aminobiphenyl, were synthesized via a facile two-step process. Reaction of pyrazolyl substituted bromophosphine with 2-aminobiphenyl derivatives and further reaction with elemental sulphur affords the corresponding thiophosphinyl amide and thiophosphonyl diamide. The intermediate species was used without prior purification for reaction with sulphur to yield the target compounds. The nematicidal activity evaluation suggests that some compounds could manifest moderate nematicidal activity towards Meloidogyne incogita, which is higher than that of their amide analogue bixafen.