Cyclic chain displacement amplification-based dual-miRNA detection: a triple-line lateral flow strip for the diagnosis of lung cancer. Issue 92 (3rd November 2021)

• Record Type: Journal Article
• Authors: Zhou, Ping; Lu, Fei; Pan, Wei; Yin, Jiaqi; Li, Na; Tang, Bo
• Is Part Of: Chemical communications. Volume 57:Issue 92(2021)
• Page Start: 12301
• Page End: 12304
• Publication Date: 2021-11-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc05442b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A dual-miRNA detection platform based on cyclic chain displacement amplification was developed for the diagnosis of lung cancer in a triple-line lateral flow strip. Abstract : Herein, we developed a triple-line lateral flow strip-based platform combined with an miRNA-initiated cyclic chain displacement reaction for the rapid and simultaneous dual-miRNA detection of lung cancer in a single strip test. The simultaneous dual-miRNA detection platform was used for the analysis of clinical serum samples, and distinguished non-small cell lung cancer patients from heathy individuals.