Alkylation of quinoxalin-2(1H)-ones using phosphonium ylides as alkylating reagents. Issue 44 (2nd November 2021)

• Record Type: Journal Article
• Authors: Peng, Sha; Liu, Jun-Jia; Yang, Luo
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 44(2021)
• Page Start: 9705
• Page End: 9710
• Publication Date: 2021-11-02
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob01858b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A practical and efficient protocol for the preparation of 3-alkylquinoxalinones through base promoted alkylation of quinoxalin-2(1 H )-ones with phosphonium ylides under metal- and oxidant-free conditions was developed. Abstract : A practical and efficient methodology for the construction of 3-alkylquinoxalinones through base promoted direct alkylation of quinoxalin-2(1 H )-ones with phosphonium ylides as alkylating reagents under metal- and oxidant-free conditions was developed. Various 3-alkylquinoxalin-2(1 H )-ones were easily obtained in good to excellent yields. Tentative mechanistic studies suggest that this reaction is likely to involve a nucleophilic addition–elimination process.