Diurnal variations in luminal and stromal areas of choroid in normal eyes. Issue 3 (13th June 2016)

• Record Type: Journal Article
• Authors: Kinoshita, Takamasa; Mitamura, Yoshinori; Shinomiya, Kayo; Egawa, Mariko; Iwata, Akiko; Fujihara, Akiko; Ogushi, Yoko; Semba, Kentaro; Akaiwa, Kei; Uchino, Eisuke; Sonoda, Shozo; Sakamoto, Taiji
• Is Part Of: British journal of ophthalmology. Volume 101:Issue 3(2017)
• Page Start: 360
• Page End: 364
• Publication Date: 2016-06-13
• Subjects: Choroid -- Imaging -- Macula -- Physiology; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2016-308594
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Aims: To determine the diurnal variations of the luminal and stromal areas of the choroid in normal eyes. Methods: This was a prospective observational study of 38 eyes of 38 normal subjects. The blood pressure, heart rate, intraocular pressure and enhanced depth imaging optical coherence tomographic (EDI-OCT) images were recorded every 3 hours between 6:00 and 21:00 hours. The horizontal EDI-OCT images of the subfoveal choroid were converted to binary images. The central choroidal thickness (CCT), total cross-sectional choroidal area, the luminal areas, stromal areas and the ratio of luminal area to total choroidal area (L/C ratio) were determined. Results: There were significant diurnal variations in the CCT, total choroidal area, luminal area and L/C ratio with the maximum values at 6:00 hours and the minimum values at 15:00 hours (p<0.001 for the CCT, p=0.011 for the total choroidal area, p<0.001 for the luminal area and p=0.014 for the L/C ratio). There was no significant variation in the stromal area (p=0.216). The range of fluctuation in the CCT was significantly correlated with that in the luminal area and the total choroidal area (p<0.001). However, there was no significant correlation between the fluctuation range in the CCT and that in the stromal area (p=0.095). There was no statistical relationship between the systemic parameters and the choroidal parameters. Conclusions: The changes in the luminal area are most likely responsible for the diurnal change in the CCT and subfoveal choroidal area. Trial registration number: UMIN000019060, Pre-results.