LepR-Expressing Stem Cells Are Essential for Alveolar Bone Regeneration. (October 2020)

• Record Type: Journal Article
• Authors: Zhang, D.; Zhang, S.; Wang, J.; Li, Q.; Xue, H.; Sheng, R.; Xiong, Q.; Qi, X.; Wen, J.; Fan, Y.; Zhou, B.O.; Yuan, Q.
• Is Part Of: Journal of dental research. Volume 99:Number 11(2020)
• Page Start: 1279
• Page End: 1286
• Publication Date: 2020-10
• Subjects: leptin receptor -- stem cells -- cell lineage -- osteogenesis -- PTH-PTHrP receptor -- tooth extraction; Dentistry -- Periodicals; Dentistry -- Social aspects -- Periodicals; Dentistry -- Periodicals; Research -- Periodicals; 617.6005
• DOI: 10.1177/0022034520932834
• Languages: English
• ISSNs: 0022-0345

Abstract

Stem cells play a critical role in bone regeneration. Multiple populations of skeletal stem cells have been identified in long bone, while their identity and functions in alveolar bone remain unclear. Here, we identified a quiescent leptin receptor–expressing (LepR + ) cell population that contributed to intramembranous bone formation. Interestingly, these LepR + cells became activated in response to tooth extraction and generated the majority of the newly formed bone in extraction sockets. In addition, genetic ablation of LepR + cells attenuated extraction socket healing. The parabiosis experiments revealed that the LepR + cells in the healing sockets were derived from resident tissue rather than peripheral blood circulation. Further studies on the mechanism suggested that these LepR + cells were responsive to parathyroid hormone/parathyroid hormone 1 receptor (PTH/PTH1R) signaling. Collectively, we demonstrate that LepR + cells, a postnatal skeletal stem cell population, are essential for alveolar bone regeneration of extraction sockets.