Recurrent Glioma: Does Qualitative Simultaneous 18F-DOPA PET/mp-MRI Improve Diagnostic Workup? An Initial Experience. (September 2021)

• Record Type: Journal Article
• Authors: Jena, Amarnath; Taneja, Sangeeta; Khan, Anna Ara; Sogani, Shanti K.
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 9(2021)
• Publication Date: 2021-09
• Subjects: radiation necrosis -- glioma recurrence -- simultaneous PET/MRI -- amino acid PET -- multiparametric; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003728
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Rationale of the Study: Neuroimaging modalities such as contrast-enhanced MRI and PET provide significant insight in the evaluation of gliomas. However, their reliability in successfully differentiating the tumor recurrence with treatment-related changes is still technologically challenging. The current study aims to qualitatively investigate the potential of the hybrid PET/multiparametric MRI modality to noninvasively distinguish between these 2 outcomes of brain tumor diagnostics for optimum and early patient management. Patients and Methods: A cohort of 26 suspected recurrent glioma cases proved on histology and/or clinicoradiological outcome forms the part of this study. A 3-point visual analytical scale was used to qualify lesions as recurrent or posttreatment radiation effects on PET, conventional MRI, dynamic susceptibility contrast–perfusion-weighted imaging, apparent diffusion coefficient, and the MR spectroscopy according to their level of suspicion. Results: Of the 26 patients, 21 patients were classified as recurrence and 5 as radiation necrosis. Advanced MRI parameters (perfusion, diffusion, and spectroscopy) integrated with 18 F-DOPA PET imaging resulted in superior diagnostic performance obtained on visual assessment with an accuracy of 95%, sensitivity of 96%, and specificity approaching up to 100% over individual modalities. Conclusions: The combination of multiple MR parameters evaluated together with 18 F-DOPA PET offers an attractive approach to noninvasively distinguish true recurrence from radiation necrosis. However, further prospective studies with larger cohorts are warranted with additional neuropathological validations.