Exploration of immune-related cells and ceRNA in squamous cell lung cancer. Issue 35 (3rd September 2021)

• Record Type: Journal Article
• Authors: Wang, Lijun; Wang, Hao; Xu, Ke; Xu, Yehong; Wang, Yong; Wei, Song; Zhang, Zhihong
• Other Names: Jaiswal. Hemant section editor.
• Is Part Of: Medicine. Volume 100:Issue 35(2021)
• Publication Date: 2021-09-03
• Subjects: ceRNA -- CIBERSORT -- prognosis -- SqCLC -- TCGA; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000027058
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: The treatment for squamous cell lung cancer (SqCLC) is limited, and the prognosis of SqCLC is poor. In this article, we aimed to analyze and identify immune-related cells and competition endogenous RNA (ceRNA) that influence the prognosis of SqCLC. SqCLC and lung adenocarcinoma data were downloaded from TCGA-GDC. A total of 22 types of immune cell fractions were estimated using CIBERSORT. R software was used to identify any significantly different transcriptome data, including mRNA, LncRNA, and miRNA. The univariate cox regression method was applied to screen for prognosis-related lncRNA, miRNA, mRNA and tumor-infiltrating immune cells. There were 504 patients included in this study. There was a higher proportion of memory activated CD4+ T cells and CD8+ T cells in younger women. Follicular helper T (Tfh) cells were predictive of a good prognosis and reflected immune activation in SqCLC. The SFTA1P/NKX2-1-AS1, hsa-mir-503, GREM2 ceRNA axes and NKX2-1-AS1, hsa-mir-96, PROK2 ceRNA axes were found to be important for the immune function, pathogenesis, and prognosis of SqCLC. Collectively, the immune-related ceRNA and tumor-infiltrating immune cells in SqCLC are likely important determinants of SqCLC pathogenesis, prognosis, and immune status.