PS3:62 Is there a relationship between vitamin d and complement in patients with juvenile systemic lupus erythematosus?. (21st March 2018)

• Record Type: Journal Article
• Authors: Guerra, M; Águeda, A; Jorge, I; Ferreira, R; Rodrigues, M; Brito, I
• Is Part Of: Lupus science & medicine. Volume 5(2018)Supplement 1
• Page Start: A64
• Page End: A64
• Publication Date: 2018-03-21
• Subjects: Juvenile SLE -- Vitamin D -- Complement; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1136/lupus-2018-abstract.108
• Languages: English
• ISSNs: 2398-8851

Abstract

Abstract : Purpose: Complement consumption is a feature of active Systemic Lupus Erythematosus (SLE), and serum complement components measurement is used in clinical practice in the surveillance of these patients. Also, vitamin D deficiency is a common finding in SLE. This study aimed to evaluate the correlation between serum levels of 25-hydroxyvitamin D (25OH-D) and C3c/C4 in patients with juvenile SLE. Methods: A population of juvenile SLE patients was retrospectively evaluated. Data on demographic and clinical characteristics was collected. Serum 25-OH-colecalciferol (normal >30 ng/ml), C3c (normal >75 mg/dl) and C4 (normal >10 mg/dl) values were also gathered. Statistical analysis was performed using Pearson and Spearman correlation coefficient. Significance level was set as <0.05. Results: Twenty-one patients were included, with a mean current age of 26, 6 years (±7, 44). Two patients were male (9, 5%). Eleven patients (52, 4%) had renal involvement: 9 with lupus nephritis class IV, 1 with class III and 1 with class II. More than half of them (63, 6%) were in maintenance treatment with mycophenolate mofetil. Considering laboratory measurements, the mean serum 25OH-D was 22, 1 ng/ml (±9, 36), mean C4 17, 5 mg/dl (±7, 29) and median C3c 105 mg/dl (from 18 to 144 mg/dl). Only 14, 3% (n=3) had serum 25OH-D above 30 ng/ml; 19, 0% (n=4) had low C3c levels and 9, 5% (n=2) low C4 levels. When correlating 25OH-D with C3c values, no statistical significant difference was found (r=0, 005; p=0.9843). The same occurred with 25OH-D and C4 (r=0, 127; p=0.5843). Conclusion: Vitamin D has an important role on the immune system modulation, but still not fully understood. In SLE, other authors have described a positive correlation between serum levels of 25OH-D and complement components levels. Despite the small sample size, this hypothesis was not confirmed in the presented population.