Evaluation of the synergistic antimicrobial effect of folk medicinal plants with clindamycin against methicillin‐resistant Staphylococcus aureus strains. (4th October 2021)

• Record Type: Journal Article
• Authors: Mayyas, A.; Azzam, H.; Tayseer, I.; Al‐Karablieh, N.; Aburjai, T.
• Is Part Of: Letters in applied microbiology. Volume 73:Number 6(2021)
• Page Start: 735
• Page End: 740
• Publication Date: 2021-10-04
• Subjects: antibiotic resistance -- clindamycin -- folk medicinal plant -- methicillin‐resistant Staphylococcus aureus -- MIC -- synergism; Microbiology -- Periodicals; 660.62
• DOI: 10.1111/lam.13565
• Languages: English
• ISSNs: 0266-8254

Abstract

Abstract: Antibiotic resistance has become a major worldwide priority, and identifying natural antimicrobial compounds may help overcome this problem. In this study, ethanolic extracts of 12 plants commonly used in traditional medicine were tested against two strains of methicillin‐resistant Staphylococcus aureus (ATCC 33591 and ATCC 43300) in terms of minimum inhibitory concentrations (MICs). Furthermore, the effect of combining plant extracts with clindamycin antibiotic was also investigated using the checkerboard method. Among the tested plants, Camellia sinensis, Thymus vulgaris, Rosmarinus officinalis and Salvia officinalis exhibited potent inhibitory activity against both strains with MICs ranges (125–500 µg ml −1 ). Synergistic activity was confirmed for the four plants combined with clindamycin with fractional inhibitory concentration index <0·5. However, no antagonistic activity was found for these combinations. Our findings suggest that using an antibiotics‐plants combination might be a successful technique to reduce antibiotic consumption, which would overcome the antibiotics resistance or delay its onset. Abstract : Significance and Impact of the Study: Medicinal plants are traditionally used in Jordan for the treatment of different infections; numerous are reported to possess antibacterial activity against Staphylococcus aureus strains. Introducing safe drugs of natural origin to overcome the resistance problem and the side effect of common treatments have always been of great interest to scientists working in this field. In which the overall effect may act synergistically to inhibit bacterial growth.