Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex. Issue 18 (29th September 2021)

• Record Type: Journal Article
• Authors: Takeuchi, Hikaru; Kimura, Ryosuke; Tomita, Hiroaki; Taki, Yasuyuki; Kikuchi, Yoshie; Ono, Chiaki; Yu, Zhiqian; Matsudaira, Izumi; Nouchi, Rui; Yokoyama, Ryoichi; Kotozaki, Yuka; Nakagawa, Seishu; Hanawa, Sugiko; Iizuka, Kunio; Sekiguchi, Atsushi; Araki, Tsuyoshi; Miyauchi, Carlos Makoto; Ikeda, Shigeyuki; Sakaki, Kohei; dos S. Kawata, Kelssy H.; Nozawa, Takayuki; Yokota, Susumu; Magistro, Daniele; Imanishi, Tadashi; Kawashima, Ryuta
• Is Part Of: Human brain mapping. Volume 42:Issue 18(2021)
• Page Start: 6028
• Page End: 6037
• Publication Date: 2021-09-29
• Subjects: bipolar disorder -- creativity -- polygenic risk score -- prefrontal cortex -- voxel‐based morphometry; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.25667
• Languages: English
• ISSNs: 1065-9471

Abstract

ABSTRACT: It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD‐PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole‐brain voxel‐by‐voxel analyses, we examined these potential associations in 1558 young, typically developing adult students. After adjusting for confounding variables and multiple comparisons, a greater BD‐PRS was associated with a greater total CMDT fluency score, and a significant relationship was found in fluency subscores. A greater BD‐PRS was also associated with lower total mood disturbance. Neuroimaging analyses revealed that the BD‐PRS was associated with greater rGMV in the right inferior frontal gyrus, which is a consistently affected area in BD, as well as a greater rWMV in the left middle frontal gyrus, which has been suggested to play a central role in the increased creativity associated with the risk of BD with creativity. These findings suggest a relationship between the genetic risk of BD and CMDT and prefrontal cortical structures among young educated individuals. Abstract : We used brain structural imaging, genome‐wide gene polymorphism data, and creativity data as measured by divergent thinking. And we showed that a higher genetic risk of bipolar disorder is associated with higher creativity and prefrontal cortical gray matter/white matter volume in young adults.