Chemical synthesis of polysaccharide–protein and polysaccharide–peptide conjugates: A review. (15th November 2021)

• Record Type: Journal Article
• Authors: Zhou, Yang; Petrova, Stella P.; Edgar, Kevin J.
• Is Part Of: Carbohydrate polymers. Volume 274(2021)
• Publication Date: 2021-11-15
• Subjects: Polysaccharide-protein conjugates -- Chemical conjugation -- Protein pharmaceuticals -- Drug delivery; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118662
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Polysaccharides are abundant natural polymers, which in nature are at times covalently modified with peptides and proteins. Polysaccharide–protein or polysaccharide–peptide conjugates, natural or otherwise, may have increased solubility, improved emulsion properties, prolonged circulation time, reduced immunogenicity, and enhanced selectivity for targeting specific tissues compared to native peptides and proteins. In this paper, we will review recent advances in synthetic methods for producing polysaccharide–protein conjugates and discuss their advantages with a focus on drug targeting. Graphical abstract: Unlabelled Image Highlights: Advances in chemical synthesis of polysaccharide-protein conjugates reviewed Enhanced properties of polysaccharide-protein conjugates described Challenges in synthetic methods discussed