Catalyst‐Free Hydrogen Proton Transfer Reduction of Nitrobenzamides to Aminobenzamides with iPrOH/KOH System. Issue 11 (23rd September 2021)

• Record Type: Journal Article
• Authors: Bai, Xueying; Huang, Liliang; Qing, Bin; Zuo, Zhicheng; Feng, Huangdi
• Is Part Of: Asian journal of organic chemistry. Volume 10:Issue 11(2021)
• Page Start: 2892
• Page End: 2894
• Publication Date: 2021-09-23
• Subjects: reduction -- metal-free -- nitro compounds -- amines -- benzamides; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202100511
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: A reduction of nitrobenzenes via the combination of KOH and isopropanol was established for the general synthesis of aniline derivatives. A metal catalyst isn't required in this alternative reduction reaction, and a series of nitrobenzamide compounds were chemoselectively reduced into the corresponding aminobenzamides in good to excellent yields. This reaction is operationally simple, and proceeds under mild conditions. Abstract : The chemoselective hydrogen proton transfer reduction of nitrobenzamides to aminobenzamides has been established. This reaction realized the first i PrOH/KOH reduction system for the nitro reduction in the absence of metal catalyst.