A Biofilm Microenvironment‐Activated Single‐Atom Iron Nanozyme with NIR‐Controllable Nanocatalytic Activities for Synergetic Bacteria‐Infected Wound Therapy. Issue 22 (7th October 2021)

• Record Type: Journal Article
• Authors: Xu, Qiqi; Hua, Yusheng; Zhang, Yuetong; Lv, Mingzhu; Wang, Huan; Pi, Yang; Xie, Jiani; Wang, Chengyan; Yong, Yuan
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 22(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-07
• Subjects: activatable nanoplatforms -- antibacterial and anti‐infection -- biofilm microenvironment -- chemodynamic and photothermal therapy -- single‐atom nanozymes; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202101374
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Biofilm microenvironment (BME)‐activated antimicrobial agents display great potential for improved biofilm‐related infection therapy because of their superior specificities and sensitivities, effective eliminations, and minimal side effects. Herein, BME‐activated Fe‐doped polydiaminopyridine nanofusiform‐mediated single‐atom nanozyme (FePN SAzyme) is presented for photothermal/chemodynamic synergetic bacteria‐infected wound therapy. The photothermal therapy (PTT) function of SAzyme can be specifically initiated by the high level of H2 O2 and further accelerated through mild acid within the inflammatory environment through "two‐step rocket launching‐like" process. Additionally, the enhanced chemodynamic therapy (CDT) for the FePN SAzyme can also be endowed by producing hydroxyl radicals through reacting with H2 O2 and consuming glutathione (GSH) of the BME, thereby contributing to more efficient synergistic therapeutic effect. Meanwhile, FePN SAzyme could catalyze biofilm‐overexpressed H2 O2 decomposing into O2 and overcome the hypoxia of biofilm, which significantly enhances the susceptibility of biofilm and increases the synergistic efficacy. Most importantly, the synergistic therapy of bacterial‐induced infection diseases can be switched on by the internal and external stimuli simultaneously, resulting in minimal nonspecific damage to healthy tissue. These remarkable characteristics of FePN SAzyme not only develop an innovative strategy for the BME‐activated combination therapy but also open a new avenue to explore other nanozyme‐involved nanoplatforms for bacterial biofilm infections. Abstract : A biofilm microenvironment‐activated Fe‐doped polydiaminopyridine nanofusiform‐mediated single‐atom nanozyme (FePN SAzyme) is fabricated successfully for local hyperthermia‐combined chemodynamic therapy of bacteria‐infected wound therapy. This work not only provides a representative H2 O2 /acid‐activated SAzyme‐based paradigm for biofilm‐targeted specific synergistic therapy of bacteria‐infected diseases but also promotes the development of other SAzyme in the areas of healthcare.