Asymmetric Stepwise Reductive Amination of Aryl N‐Heteroaryl Ketones with Benzyl Amines via Iridium Catalysis. Issue 11 (30th September 2021)

• Record Type: Journal Article
• Authors: Yang, Bing; Fu, Hao; Yuan, Jing; Wen, Simiaomiao; Wang, Chunqin; Liu, Qixing; Zhou, Haifeng
• Is Part Of: Asian journal of organic chemistry. Volume 10:Issue 11(2021)
• Page Start: 2950
• Page End: 2953
• Publication Date: 2021-09-30
• Subjects: Asymmetric reductive amination -- Aryl N-heteroaryl methylamines -- Iridium -- Enantioselectivity; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202100472
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: An asymmetric reductive amination of aryl N‐heteroaryl ketones with Benzyl Amines has been realized via one‐pot two‐step process, using p‐toluenesulfonic acid and chiral iridium complexes as catalysts, a mixture of formic acid/triethylamine as a reductant. Twenty‐three examples of chiral aryl N‐heteroaryl methylamines were obtained with good yields and up to 99% ee. Abstract : Various chiral aryl N‐heteroaryl methylamines were prepared with good yields and up to 99% enantioselectivity via one‐pot stepwise ketimine formation/asymmetric transfer hydrogenation of aryl N‐heteroaryl ketones and benzyl amines.