Ferritin level: A predictor of severity and mortality in hospitalized COVID‐19 patients. Issue 4 (26th August 2021)

• Record Type: Journal Article
• Authors: Alroomi, Moudhi; Rajan, Rajesh; Omar, Abdulaziz A.; Alsaber, Ahmad; Pan, Jiazhu; Fatemi, Mina; Zhanna, Kobalava D.; Aboelhassan, Wael; Almutairi, Farah; Alotaibi, Naser; Saleh, Mohammad A.; AlNasrallah, Noor; Al‐Bader, Bader; Malhas, Haya; Ramadhan, Maryam; Abdullah, Mohammed; Abdelnaby, Hassan
• Is Part Of: Immunity, inflammation and disease. Volume 9:Issue 4(2021)
• Page Start: 1648
• Page End: 1655
• Publication Date: 2021-08-26
• Subjects: COVID‐19 -- ferritin -- hypertension -- in‐hospital mortality -- male sex -- pneumonia -- SARS‐CoV‐2; Immunology -- Periodicals; Immunity -- Periodicals; Inflammation -- Periodicals; 616.079
• DOI: 10.1002/iid3.517
• Languages: English
• ISSNs: 2050-4527

Abstract

Аbstrасt: Introduction: This study aims to investigate in‐hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels. Methods: Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000). Results: Approximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21–0.62; p < .001), male sex (OR = 2.63, 95% CI = 1.43–5.06; p = .003), hypertension (OR = 4.16, 95% CI = 2.42–7.36; p < .001) and pneumonia (OR = 8.48, 95% CI = 3.02–35.45; p < .001) had significance in predicting in‐hospital mortality. Additionally, the Cox proportional hazards analysis and Kaplan–Meier survival probability plot showed a higher mortality rate among patients with ferritin levels > 1000. Conclusion: In this study, higher levels of serum ferritin were found to be an independent predictor of in‐hоsрitаl mоrtаlity.