Numerical evaluation of cardiac mechanical markers as estimators of the electrical activation time. (7th January 2020)

• Record Type: Journal Article
• Authors: Colli Franzone, Piero; Pavarino, Luca F.; Scacchi, Simone
• Is Part Of: International journal for numerical methods in biomedical engineering. Volume 37:Number 11(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-07
• Subjects: bidomain model -- cardiac electromechanical coupling -- electrical and mechanical activation time -- electromechanical delay -- finite elasticity -- parallel numerical simulations; Biomedical engineering -- Periodicals; Imaging systems in medicine -- Periodicals; Numerical analysis -- Periodicals; Engineering mathematics -- Periodicals; 610.28
• DOI: 10.1002/cnm.3285
• Languages: English
• ISSNs: 2040-7939

Abstract

Abstract: Recent advances in the development of noninvasive cardiac imaging technologies have made it possible to measure longitudinal and circumferential strains at a high spatial resolution also at intramural level. Local mechanical activation times derived from these strains can be used as noninvasive estimates of electrical activation, in order to determine, eg, the origin of premature ectopic beats during focal arrhythmias or the pathway of reentrant circuits. The aim of this work is to assess the reliability of mechanical activation time markers derived from longitudinal and circumferential strains, denoted by AT ell and AT ecc, respectively, by means of three‐dimensional cardiac electromechanical simulations. These markers are compared against the electrical activation time (AT v ), computed from the action potential waveform, and the reference mechanical activation markers derived from the active tension and fiber strain waveforms, denoted by AT ta and AT eff, respectively. Our numerical simulations are based on a strongly coupled electromechanical model, including bidomain representation of the cardiac tissue, mechanoelectric (ie, stretch‐activated channels) and geometric feedbacks, transversely isotropic strain energy function for the description of passive mechanics and detailed membrane and excitation‐contraction coupling models. The results have shown that, during endocardial and epicardial ectopic stimulations, all the mechanical markers considered are highly correlated with AT v, exhibiting correlation coefficients larger than 0.8. However, during multiple endocardial stimulations, mimicking the ventricular sinus rhythm, the mechanical markers are less correlated with the electrical activation time, because of the more complex resulting excitation sequence. Moreover, the inspection of the endocardial and epicardial isochrones has shown that the AT ell and AT ecc mechanical activation sequences reproduce only some qualitative features of the electrical activation sequence, such as the areas of early and late activation, but in some cases, they might yield wrong excitation sources and significantly different isochrones patterns. Abstract : Cardiac mechanical activation times derived from longitudinal or circumferential strains can be used as noninvasive estimates of electrical activation, with the aim of identifying, eg, the origin of premature ectopic beats during focal arrhythmias or the pathway of reentrant circuits. The aim of this work is to assess the reliability of mechanical activation time markers by means of three‐dimensional cardiac electromechanical simulations. The results have shown that the mechanical activation sequences reproduce the same qualitative features of the electrical activation sequence, with the same location of areas of early and late activation.